# 21662: Current combination of 'From' and 'To' parameters cannot be used in Ireland region

Log Type: APPLICATION

Log Level: ERROR

## Description

This error occurs when you attempt to send an outbound message as a data resident workload in the Ireland Region (`IE1`), but the message uses a North American (+1) number in the `From` or `To` parameter. Twilio cannot process that `From` and `To` combination in `IE1`.

### Possible causes

* You sent the message from a North American (+1) sender while targeting the Ireland Region (`IE1`).
* You sent the message to a North American (+1) destination while targeting the Ireland Region (`IE1`).
* Your API request or SDK configuration targeted `IE1` for a messaging workload that should be processed in another Region. Twilio processes requests in the Region you select, and if you do not specify a Region, Twilio uses `US1` by default.

### Possible solutions

* Do not send data resident messages in `IE1` when the `From` or `To` value is a North American (+1) number. Use a supported sender and recipient combination for the Ireland Region instead.
* If you need to send a message from or to a North American (+1) number, send that request through the default `US1` Region instead of `IE1`. Twilio handles requests in `US1` when you do not explicitly target another Region.
* Review your API hostname or SDK client settings and remove the `IE1` target for this request if the message must use a +1 number. For REST API requests, the hostname determines the processing Region. For server-side SDKs, the `edge` and `region` settings determine the target Region.
* If you are using SMS data residency in Europe, confirm that your use case is configured for the Ireland Region and that the sender and recipient combination matches the constraints of that regional workload.

#### Additional resources

* [Using the Twilio REST API in a non-US Region](/docs/global-infrastructure/using-the-twilio-rest-api-in-a-non-us-region)
* [Twilio Regions](/docs/global-infrastructure/understanding-twilio-regions)
* [Send SMS and MMS messages](/docs/messaging/tutorials/how-to-send-sms-messages)